Qt with SCons
From qtnode
Though qmake does it perfectly for small projects, it does not handle the configuration, and this can be a real issue when the project grows up. Autotools are not portable to win32 and are being progressively left aside for important projects like KDE. Among alternatives, you can find cmake or bksys.
The next bksys version is not ready yet, but it already compiles Qt4 projects as seen on the bksys page.
SCons without bksys
David Garcia Garzon contributed this Qt4 tool for SCons.